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dc.contributor.authorBhattacharjee, Rajesh
dc.contributor.authorSil, Parames Chandra
dc.date.accessioned2013-03-15T12:02:43Z
dc.date.available2013-03-15T12:02:43Z
dc.date.issued2006-01-01
dc.identifierFOR ACCESS / DOWNLOAD PROBLEM -- PLEASE CONTACT LIBRARIAN, BOSE INSTITUTE, akc@bic.boseinst.ernet.inen_US
dc.identifier.citationBattachatjee Rand Sil PC (2006) Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity. Biomed Res.ll, 75-79en_US
dc.identifier.issn0970938X
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dc.identifier.urihttp://www.scopus.com/record/display.url?eid=2-s2.0-33645664263&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=44A4E27091FF2E06F04036134F3C9DD8.WeLimyRvBMk2ky9SFKc8Q%3a140&sot=aut&sdt=a&sl=40&s=AU-ID%28%22Sil%2c+Parames+Chandra%22+8905976000%29&relpos=47&relpos=7&searchTerm=AU-ID%28\%26quot%3BSil%2C+Parames+Chandra\%26quot%3B+8905976000%29#en_US
dc.description.abstractPhyllanthus niruri L. (Euphorbiaceae) is a well-known hepatoprotective herbal plant. The aim of this study was to investigate the hepatoprotective action of the protein isolate of Phyllanthus niruri (P. niruri) against acetaminophen (APAP) induced hepatotoxicity. Protein isolate of P. niruri was intraperitoneally injected in mice either prior to (preventive) or after the induction of toxicity (curative). Levels of different liver marker enzymes in serum were measured in normal, control (toxicity induced) and protein isolate treated mice. Protein isolate of P. niruri significantly reduced the elevated Glutamate Pyruvate Transaminase (GPT), and Lactate dehydrogenase (LDH) levels in sera of toxicity induced mice, compared to the control group. Treatment with the protein isolate of P. niruri also enhanced depleted hepatic glutathione (GSH) levels caused by APAP administration. In addition, histological studies supported these results and clearly showed that the protein isolate act as a hepatoprotective agent against APAP-induced toxicity. Combining, data suggest that the protein isolate of P. niruri protects liver tissues against APAP induced hepatic damage.en_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.subjectAcetaminophenen_US
dc.subjectHepatoprotectionen_US
dc.subjectHepatotoxicityen_US
dc.subjectPhyllanthus nirurien_US
dc.subjectProtein isolateen_US
dc.titleProtein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicityen_US
dc.title.alternativeBiomedical Researchen_US
dc.typeArticleen_US


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