Now showing items 1-10 of 42
Protein complex forming ability is favored over the features of interacting partners in determining the evolutionary rates of proteins in the yeast protein-protein interaction networks
(BioMed Central Ltd, 2010-11-12)
Background: Evolutionary rates of proteins in a protein-protein interaction network are primarily governed by the protein connectivity and/or expression level. A recent study revealed the importance of the features of ...
Understanding the Effect of Secondary Structures and Aggregation on Human Protein Folding Class Evolution
Using several model organisms it has been shown earlier that protein designability is related to contact density or fraction of buried residues and influence protein evolutionary rates dramatically. Here, using Homo ...
Exploring the differences in evolutionary rates between monogenic and polygenic disease genes in human.
(Oxford University Press, 2010-04)
Comparative analyses on disease and nondisease (ND) genes have greatly facilitated the understanding of human diseases. However, most studies have grouped all the disease genes together and have performed comparative ...
New Direction to the Solution of Protein Folding Problem
No abstract available.
Insights into the genomic features and evolutionary impact of the genes configuring duplicated pseudogenes in human
(ELSEVIER SCIENCE, 2010-09-24)
Pseudogenes, regarded as 'genomic fossils', are DNA sequences resembling functional genes in perspective of sequence homology but completely non-functional. In this study, we explored the unique characteristic features of ...
Protein Connectivity and Protein Complexity Promotes Human Gene Duplicability in a Mutually Exclusive Manner
(OXFORD UNIV PRESS, 2010-10)
It has previously been reported that protein complexity (i.e. number of subunits in a protein complex) is negatively correlated to gene duplicability in yeast as well as in humans. However, unlike in yeast, protein ...
Relationship between Gene Compactness and Base Composition in Rice and Human Genome
In human, highly expressed genes contain shorter and fewer introns and these have been attributed to selection for economy in transcription and translation. On the other hand, in plants, it has been shown that highly ...
Investigation of the molecular evolution of nitrogen fixation using nucleotide triplet based condensed matrix method
Evolutionary history of nitrogen fixation has been retraced by analyzing nif H, D and K genes, and whole genomes from cyanobacteria, proteobacteria, clostridia, actinobacteria, green sulfur bacteria and archaea using ...
Genomic adaptation of prokaryotic organisms at high temperature.
(Biomedical Informatics, 2010-02-28)
One of the central issues of evolutionary genomics is to find out the adaptive strategies of microorganisms to stabilize nucleic acid molecules under high temperature. Thermal adaptation hypothesis gives a link between G+C ...
On nucleotide solvent accessibility in RNA structure
(ELSEVIER SCIENCE, 2010-09-01)
Sequence dependence of solvent accessibility in globular and membrane proteins is well established. However, this important structural property has been poorly investigated in nucleic acids. On the other hand investigation ...