Now showing items 1-10 of 33
Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio
(ELSEVIER SCI IRELAND LTD, 2004-06-25)
It is known that cancer is associated with altered immune function. We demonstrated earlier that black tea inhibits tumor growth in a dose-dependent manner. Here, we report that apoptosis was the cause of immunocyte death ...
Tumor-induced dysfunction in T lymphocytes: increased sensitivity to apoptosis
Gain of Cellular Adaptation Due to Prolonged p53 Impairment Leads to Functional Switchover from p53 to p73 during DNA Damage in Acute Myeloid Leukemia Cells
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2010-10-22)
Although it has been well established that spermatogenic cells undergo apoptosis when treated with ethanol, the molecular mechanisms behind it remain to be investigated. Adult male mice were given intra-peritoneal injection ...
Tumor-Shed PGE(2) Impairs IL2R gamma c-Signaling to Inhibit CD4(+) T Cell Survival: Regulation by Theaflavins
(PUBLIC LIBRARY SCIENCE, 2009-10-08)
Background: Many tumors are associated with decreased cellular immunity and elevated levels of prostaglandin E2 (PGE2), a known inhibitor of CD4+ T cell activation and inducer of type-2 cytokine bias. However, the role of ...
A Novel Copper Chelate Modulates Tumor Associated Macrophages to Promote Anti-Tumor Response of T Cells
(PUBLIC LIBRARY SCIENCE, 2009-09-16)
Background: At the early stages of carcinogenesis, the induction of tumor specific T cell mediated immunity seems to block the tumor growth and give protective anti-tumor immune response. However, tumor associated macrophages ...
Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells
(OXFORD UNIV PRESS, 2010-02)
The most common alterations found in breast cancer are inactivation or mutation of tumor suppressor gene p53. The present study revealed that theaflavins induced p53-mutated human breast cancer cell apoptosis. Pharmacological ...
Effect of renal cell carcinomas on the development of type 1 T-cell responses( Conference Paper )
(AMER ASSOC CANCER RESEARCH, 2004-09-15)
Purpose: We reported that in renal cell carcinoma patients with active disease, T-cell reactions to the tumor-associated antigens MAGE-6 and EphA2 are highly skewed toward T(H)2-type cytokine responses [interleukin (IL) ...
Black tea-induced amelioration of hepatic oxidative stress through antioxidative activity in EAC-bearing mice
(BEGELL HOUSE INC, 2007)
It is recognized that during cancer, the disease itself as well as many of the anticancer drugs in use produce undesirable side effects such as hepatotoxicity. We have already demonstrated the antitumor and immunorestoring ...
Theaflavins retard human breast cancer cell migration by inhibiting NF-kappa B via p53-ROS cross-talk
(ELSEVIER SCIENCE, 2010-01-04)
The present study demonstrates that theaflavins exploit p53 to impede metastasis in human breast cancer cells. Our data suggest that p53-dependent reactive oxygen species (ROS) induce p53-phosphorylation via p38MAPK in a ...
Multifocal signal modulation therapy of cancer: ancient weapon, modern targets
Although safe in most cases, ancient treatments are ignored because neither their active components nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and ...