Now showing items 1-6 of 6
Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: Therapeutic potential of arjunolic acid
(ELSEVIER IRELAND, 2010-01-31)
Acetaminophen (APAP) causes acute and chronic renal failure. The mechanisms leading to hepatic injury have been extensively studied, but the molecular mechanisms regarding APAP-induced nephro-toxicity are poorly defined. ...
Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation
(ELSEVIER IRELAND, 2010-02-28)
Acute exposure of acetaminophen (APAP), a widely used analgesic and antipyretic drug, causes severe renal damage and no specific agent has been reported so far that plays any beneficial role in this organ pathophysiology. ...
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1
(TAYLOR & FRANCIS, 2010-03)
The present study was carried out to investigate whether taurine plays any beneficial role in acetaminophen (APAP)-induced acute hepatotoxicity. APAP exposure increased the plasma levels of ALT, ALP, LDH, TNF-alpha and NO ...
Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection
(ELSEVIER SCIENCE, 2010-02-15)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug and is safe at therapeutic closes but its overdose frequently causes liver injury. In earlier studies, we demonstrated that arjunolic acid (AA) has a ...
Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-kappa B pathway: Role of a novel plant protein
(ELSEVIER IRELAND, 2009-01-27)
Oxidative stress is a major cause of drug induced hepatic diseases. The present study aims to investigate the antioxidative signaling mechanism of a protein isolated from the herb, Cajanus indicus against acetaminophen ...
Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity
Phyllanthus niruri L. (Euphorbiaceae) is a well-known hepatoprotective herbal plant. The aim of this study was to investigate the hepatoprotective action of the protein isolate of Phyllanthus niruri (P. niruri) against ...