Now showing items 1-2 of 2
Regulation of myotrophin gene by pressure overload and stretch
(KLUWER ACADEMIC PUBL, 2004-07-01)
Hemodynamic load is a major determinant of cardiac mass and its phenotype, but very little is known about how mechanical load is converted into intracellular signals of gene expression and regulation. We have shown earlier ...
Cardiac Overexpression of Myotrophin Triggers Myocardial Hypertrophy and Heart Failure in Transgenic Mice
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-05-07)
Cardiac hypertrophy and heart failure remain leading causes of death in the United States. Many studies have suggested that, under stress, myocardium releases factors triggering protein synthesis and stimulating myocyte ...